It sounds like you are dealing with a very severe case of bumblefoot (bacterial pododermatitis). One thing you can do is clean their legs with chlorhexadine three times daily. I also recommend changing their bedding to Carefresh instead of any of the shavings for the time being. Change the bedding frequently to avoid adding to the problem with soiled litter. If you can I would recommend trying to get an xray on at least the worst patient to evaluate whether infection has gotten to the bone. Since the enrofloxacin is not effective it may be time to consider chloramphenicol or trimethoprim-sulfa and dexamethasone.
Please let me know if further assistance is needed.
Theresa
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